A Crack in Creation

A Crack in Creation Pdf

A Crack in Creation

Author: Jennifer A. Doudna,Samuel H. Sternberg

Publisher: Houghton Mifflin Harcourt

ISBN: 0544716965

Genre: Science

Page: 320

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Book Summary: BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY Finalist for the Los Angeles Times Book Prize “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “Required reading for every concerned citizen.” — New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “An invaluable account . . . We owe Doudna several times over.” — Guardian


Sprint

Sprint Pdf

Sprint

Author: Jake Knapp,John Zeratsky,Braden Kowitz

Publisher: Simon and Schuster

ISBN: 1501121774

Genre: Business & Economics

Page: 288

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Book Summary: NEW YORK TIMES BESTSELLER WALL STREET JOURNAL BESTSELLER “Sprint offers a transformative formula for testing ideas that works whether you’re at a startup or a large organization. Within five days, you’ll move from idea to prototype to decision, saving you and your team countless hours and countless dollars. A must read for entrepreneurs of all stripes.” —Eric Ries, author of The Lean Startup From three partners at Google Ventures, a unique five-day process for solving tough problems, proven at more than a hundred companies. Entrepreneurs and leaders face big questions every day: What’s the most important place to focus your effort, and how do you start? What will your idea look like in real life? How many meetings and discussions does it take before you can be sure you have the right solution? Now there’s a surefire way to answer these important questions: the sprint. Designer Jake Knapp created the five-day process at Google, where sprints were used on everything from Google Search to Google X. He joined Braden Kowitz and John Zeratsky at Google Ventures, and together they have completed more than a hundred sprints with companies in mobile, e-commerce, healthcare, finance, and more. A practical guide to answering critical business questions, Sprint is a book for teams of any size, from small startups to Fortune 100s, from teachers to nonprofits. It’s for anyone with a big opportunity, problem, or idea who needs to get answers today.


Out of My Mind

Out of My Mind Pdf

Out of My Mind

Author: Sharon M. Draper

Publisher: Simon and Schuster

ISBN: 1416980458

Genre: Juvenile Fiction

Page: 304

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Book Summary: Over 1.5 million people have read the #1 New York Times bestseller Out of My Mind and discovered the brilliant mind of Melody Brooks. Out of My Mind spent two years on the New York Times bestseller list! “If there’s one book teens and parents (and everyone else) should read this year, Out of My Mind should be it.” —The Denver Post “A gutsy, candid, and compelling story. It speaks volumes.” —School Library Journal (starred review) “Unflinching and realistic.” —Kirkus Reviews (starred review) “Uplifting…This moving novel will makes activists of us all.” —Booklist (starred review) From award-winning author Sharon Draper comes a story that will forever change how we all look at anyone with a disability, perfect for fans of RJ Palacio’s Wonder. Eleven-year-old Melody is not like most people. She can’t walk. She can’t talk. She can’t write. All because she has cerebral palsy. But she also has a photographic memory; she can remember every detail of everything she has ever experienced. She’s the smartest kid in her whole school, but NO ONE knows it. Most people—her teachers, her doctors, her classmates—dismiss her as mentally challenged because she can’t tell them otherwise. But Melody refuses to be defined by her disability. And she’s determined to let everyone know it…somehow.


Precision Medicine, CRISPR, and Genome Engineering

Precision Medicine, CRISPR, and Genome Engineering Pdf

Precision Medicine, CRISPR, and Genome Engineering

Author: Stephen H. Tsang

Publisher: Springer

ISBN: 3319639048

Genre: Science

Page: 178

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Book Summary: This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.


The Road

The Road Pdf

The Road

Author: Cormac McCarthy

Publisher: Vintage

ISBN: 0307267458

Genre: Fiction

Page: 256

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Book Summary: NATIONAL BESTSELLER WINNER OF THE PULITZER PRIZE The searing, post-apocalyptic novel about a father and son's fight to survive. A father and his son walk alone through burned America. Nothing moves in the ravaged landscape save the ash on the wind. It is cold enough to crack stones, and when the snow falls it is gray. The sky is dark. Their destination is the coast, although they don't know what, if anything, awaits them there. They have nothing; just a pistol to defend themselves against the lawless bands that stalk the road, the clothes they are wearing, a cart of scavenged food—and each other. The Road is the profoundly moving story of a journey. It boldly imagines a future in which no hope remains, but in which the father and his son, "each the other's world entire," are sustained by love. Awesome in the totality of its vision, it is an unflinching meditation on the worst and the best that we are capable of: ultimate destructiveness, desperate tenacity, and the tenderness that keeps two people alive in the face of total devastation. A New York Times Notable Book One of the Best Books of the Year The Boston Globe, The Christian Science Monitor, The Denver Post, The Kansas City Star, Los Angeles Times, New York, People, Rocky Mountain News, Time, The Village Voice, The Washington Post


Paper Towns

Paper Towns Pdf

Paper Towns

Author: John Green

Publisher: Penguin

ISBN: 1101010932

Genre: Young Adult Fiction

Page: 320

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Book Summary: Winner of the Edgar Award The #1 New York Times Bestseller Publishers Weekly and USA Today Bestseller Millions of Copies Sold Quentin Jacobsen has spent a lifetime loving the magnificent Margo Roth Spiegelman from afar. So when she cracks open a window and climbs back into his life—summoning him for an ingenious campaign of revenge—he follows. When their all-nighter ends and a new day breaks, Margo has disappeared. But Q soon learns that there are clues—and they’re for him. Embarking on an exhilarating adventure to find her, the closer Q gets, the less he sees the girl he thought he knew. #1 Bestselling author of The Fault in Our Stars John Green crafts a brilliantly funny and moving coming-of-age journey about true friendship and true love.


Strengthening Forensic Science in the United States

Strengthening Forensic Science in the United States Pdf

Strengthening Forensic Science in the United States

Author: National Research Council,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Policy and Global Affairs,Committee on Science, Technology, and Law,Committee on Identifying the Needs of the Forensic Sciences Community

Publisher: National Academies Press

ISBN: 0309142393

Genre: Law

Page: 348

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Book Summary: Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.


Targeted Genome Editing Using Site-Specific Nucleases

Targeted Genome Editing Using Site-Specific Nucleases Pdf

Targeted Genome Editing Using Site-Specific Nucleases

Author: Takashi Yamamoto

Publisher: Springer

ISBN: 4431552278

Genre: Science

Page: 205

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Book Summary: This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.


The Glass Castle

The Glass Castle Pdf

The Glass Castle

Author: Jeannette Walls

Publisher: Simon and Schuster

ISBN: 9781416550600

Genre: Biography & Autobiography

Page: 304

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Book Summary: Now a major motion picture from Lionsgate starring Brie Larson, Woody Harrelson, and Naomi Watts. MORE THAN SEVEN YEARS ON THE NEW YORK TIMES BESTSELLER LIST The perennially bestselling, extraordinary, one-of-a-kind, “nothing short of spectacular” (Entertainment Weekly) memoir from one of the world’s most gifted storytellers. The Glass Castle is a remarkable memoir of resilience and redemption, and a revelatory look into a family at once deeply dysfunctional and uniquely vibrant. When sober, Jeannette’s brilliant and charismatic father captured his children’s imagination, teaching them physics, geology, and how to embrace life fearlessly. But when he drank, he was dishonest and destructive. Her mother was a free spirit who abhorred the idea of domesticity and didn’t want the responsibility of raising a family. The Walls children learned to take care of themselves. They fed, clothed, and protected one another, and eventually found their way to New York. Their parents followed them, choosing to be homeless even as their children prospered. The Glass Castle is truly astonishing—a memoir permeated by the intense love of a peculiar but loyal family.


Rebel Without a Cause

Rebel Without a Cause Pdf

Rebel Without a Cause

Author: J. David Slocum

Publisher: SUNY Press

ISBN: 0791482340

Genre: Social Science

Page: 269

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Book Summary: Assesses the layered meanings and persistent global legacy of an American film classic.


A New Earth (Oprah #61)

A New Earth (Oprah #61) Pdf

A New Earth (Oprah #61)

Author: Eckhart Tolle

Publisher: Penguin

ISBN: 1101010894

Genre: Self-Help

Page: 336

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Book Summary: The 10th anniversary edition of A New Earth with a new preface by Eckhart Tolle. With his bestselling spiritual guide The Power of Now, Eckhart Tolle inspired millions of readers to discover the freedom and joy of a life lived “in the now.” In A New Earth, Tolle expands on these powerful ideas to show how transcending our ego-based state of consciousness is not only essential to personal happiness, but also the key to ending conflict and suffering throughout the world. Tolle describes how our attachment to the ego creates the dysfunction that leads to anger, jealousy, and unhappiness, and shows readers how to awaken to a new state of consciousness and follow the path to a truly fulfilling existence. Illuminating, enlightening, and uplifting, A New Earth is a profoundly spiritual manifesto for a better way of life—and for building a better world.


Marijuana

Marijuana Pdf

Marijuana

Author: John Hudak

Publisher: Brookings Institution Press

ISBN: 0815738323

Genre: Political Science

Page: 267

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Book Summary: From “Reefer Madness” to legal purchase at the corner store With long-time legal and social barriers to marijuana falling across much of the United States, the time has come for an accessible and informative look at attitudes toward the dried byproduct of Cannabis sativa. Marijuana: A Short History profiles the politics and policies concerning the five-leaf plant in the United States and around the world. Millions of Americans have used marijuana at some point in their lives, yet it remains a substance shrouded by myth, misinformation, and mystery. And nearly a century of prohibition has created an enforcement system that is racist, and the continuing effects of racially-targeted over criminalization limit economic and social opportunities in communities of color. Marijuana: A Short History tells this story, and that of states stepping up to enact change. This book offers an up-to-date, cutting-edge look at how a plant with a tumultuous history has emerged from the shadows of counterculture and illegality. Today, marijuana has become a remarkable social, economic, and even political force—with a surprising range of advocates and opponents. Over the past two decades marijuana policy has transformed dramatically in the United States, as dozens of states have openly defied the federal government. Marijuana: A Short History provides a brief yet compelling narrative that discusses the social and cultural history of marijuana but also tells us how a once-vilified plant has been transformed into a serious, even mainstream, public policy issue. Focusing on politics, the media, government, racism, criminal justice, and education, the book describes why public policy has changed, and what that change might mean for marijuana’s future place in society.


Life of Pi

Life of Pi Pdf

Life of Pi

Author: Yann Martel

Publisher: Houghton Mifflin Harcourt

ISBN: 0151008116

Genre: Fiction

Page: 319

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Book Summary: Possessing encyclopedia-like intelligence, unusual zookeeper's son Pi Patel sets sail for America, but when the ship sinks, he escapes on a life boat and is lost at sea with a dwindling number of animals until only he and a hungry Bengal tiger remain. 40,000 first printing.


Evolutionary and Revolutionary Technologies for Mining

Evolutionary and Revolutionary Technologies for Mining Pdf

Evolutionary and Revolutionary Technologies for Mining

Author: National Research Council,Committee on Earth Resources,Board on Earth Sciences and Resources,National Materials Advisory Board,Committee on Technologies for the Mining Industries

Publisher: National Academies Press

ISBN: 9780309169837

Genre: Science

Page: 102

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Book Summary: The Office of Industrial Technologies (OIT) of the U. S. Department of Energy commissioned the National Research Council (NRC) to undertake a study on required technologies for the Mining Industries of the Future Program to complement information provided to the program by the National Mining Association. Subsequently, the National Institute for Occupational Safety and Health also became a sponsor of this study, and the Statement of Task was expanded to include health and safety. The overall objectives of this study are: (a) to review available information on the U.S. mining industry; (b) to identify critical research and development needs related to the exploration, mining, and processing of coal, minerals, and metals; and (c) to examine the federal contribution to research and development in mining processes.


Cracks and Other Short Stories

Cracks and Other Short Stories Pdf

Cracks and Other Short Stories

Author: Munyoro, Albert

Publisher: Africa Talent Publishers

ISBN: 1779295405

Genre: Fiction

Page: 154

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Book Summary: There are little strokes that fell great oaks and often unattended cracks in a diversity of our socio-economic and political institutions can ultimately lead to a total collapse of systems. Cracks and Other Short Stories is an anthology that offers readers an insight into some of the major cracks in our personalities and institutions as a subtle means of encouraging everyone to investigate them further and seek lasting solutions for the good of humanity. Cracks signal that things are out of sorts and need timeous repair, healing and mending before systems become dysfunctional and torturous to humanity. Thus, each story in this impeccable collection deals with specific metaphorical cracks which require problem solving for the betterment of society.


The Art of Thinking Clearly

The Art of Thinking Clearly Pdf

The Art of Thinking Clearly

Author: Rolf Dobelli

Publisher: Harper Collins

ISBN: 0062359800

Genre: Psychology

Page: 384

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Book Summary: Have you ever . . . Invested time in something that, in hindsight, just wasn't worth it? Paid too much in an eBay auction? Continued to do something you knew was bad for you? Sold stocks too late, or too early? Taken credit for success, but blamed failure on external circumstances? Backed the wrong horse? These are examples of what the author calls cognitive biases, simple errors all of us make in day-to-day thinking. But by knowing what they are and how to identify them, we can avoid them and make better choices: whether in dealing with personal problems or business negotiations, trying to save money or earn profits, or merely working out what we really want in life—and strategizing the best way to get it. Already an international bestseller, The Art of Thinking Clearly distills cutting-edge research from behavioral economics, psychology, and neuroscience into a clever, practical guide for anyone who's ever wanted to be wiser and make better decisions. A novelist, thinker, and entrepreneur, Rolf Dobelli deftly shows that in order to lead happier, more prosperous lives, we don't need extra cunning, new ideas, shiny gadgets, or more frantic hyperactivity—all we need is less irrationality. Simple, clear, and always surprising, this indispensable book will change the way you think and transform your decision making—at work, at home, every day. From why you shouldn't accept a free drink to why you should walk out of a movie you don't like, from why it's so hard to predict the future to why you shouldn't watch the news, The Art of Thinking Clearly helps solve the puzzle of human reasoning.


A Crack in the Edge of the World

A Crack in the Edge of the World Pdf

A Crack in the Edge of the World

Author: Simon Winchester

Publisher: Harper Collins

ISBN: 0062277456

Genre: History

Page: 512

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Book Summary: Unleashed by ancient geologic forces, a magnitude 8.25 earthquake rocked San Francisco in the early hours of April 18, 1906. Less than a minute later, the city lay in ruins. Bestselling author Simon Winchester brings his inimitable storytelling abilities to this extraordinary event, exploring the legendary earthquake and fires that spread horror across San Francisco and northern California in 1906 as well as its startling impact on American history and, just as important, what science has recently revealed about the fascinating subterranean processes that produced it—and almost certainly will cause it to strike again.


Charlotte's Web

Charlotte's Web Pdf

Charlotte's Web

Author: E. B. White

Publisher: HarperCollins

ISBN: 0062406787

Genre: Juvenile Fiction

Page: 192

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Book Summary: This beloved book by E. B. White, author of Stuart Little and The Trumpet of the Swan, is a classic of children's literature that is "just about perfect." Illustrations in this ebook appear in vibrant full color on a full-color device and in rich black-and-white on all other devices. Some Pig. Humble. Radiant. These are the words in Charlotte's Web, high up in Zuckerman's barn. Charlotte's spiderweb tells of her feelings for a little pig named Wilbur, who simply wants a friend. They also express the love of a girl named Fern, who saved Wilbur's life when he was born the runt of his litter. E. B. White's Newbery Honor Book is a tender novel of friendship, love, life, and death that will continue to be enjoyed by generations to come. It contains illustrations by Garth Williams, the acclaimed illustrator of E. B. White's Stuart Little and Laura Ingalls Wilder's Little House series, among many other books.


The Competence of the European Union in Copyright Lawmaking

The Competence of the European Union in Copyright Lawmaking Pdf

The Competence of the European Union in Copyright Lawmaking

Author: Ana Ramalho

Publisher: Springer

ISBN: 3319282069

Genre: Law

Page: 249

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Book Summary: This book inquires into the competence of the EU to legislate in the field of copyright, and uses content analysis techniques to demonstrate the existence of a normative gap in copyright lawmaking. To address that gap, it proposes the creation of benchmarks of legislative activity, reasoning that EU secondary legislation, such as directives and regulations, should be based on higher sources of law. It investigates two such possible sources: the activity of the EU Court of Justice in the pre-legislative era and the EU treaties. From these sources, the author establishes concrete benchmarks of legislative activity, which she then tests by applying them to current EU copyright legislation. This provides examples of good and bad practices in copyright lawmaking and also shows how the benchmarks could be implemented in copyright legislation. Finally, the author offers some recommendations in this regard.


The Oxford Handbook of Asian Business Systems

The Oxford Handbook of Asian Business Systems Pdf

The Oxford Handbook of Asian Business Systems

Author: Michael A. Witt,Gordon Redding

Publisher: OUP Oxford

ISBN: 0191626554

Genre: Business & Economics

Page: 752

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Book Summary: Much of the existing literature within the "varieties of capitalism " (VOC) and "comparative business systems " fields of research is heavily focused on Europe, Japan, and the Anglo-Saxon nations. As a result, the field has yet to produce a detailed empirical picture of the institutional structures of most Asian nations and to explore to what extent existing theory applies to the Asian context. The Oxford Handbook of Asian Business Systems aims to address this imbalance by exploring the shape and consequences of institutional variations across the political economies of different societies within Asia. Drawing on the deep knowledge of 32 leading experts, this book presents an empirical, comparative institutional analysis of 13 major Asian business systems between India and Japan. To aid comparison, each country chapter follows the same consistent outline. Complementing the country chapters are eleven contributions examining major themes across the region in comparative perspective and linking the empirical picture to existing theory on these themes. A further three chapters provide perspectives on the influence of history and institutional change. The concluding chapters spell out the implications of all these chapters for scholars in the field and for business practitioners in Asia. The Handbook is a major reference work for scholars researching the causes of success and failure in international business in Asia.